Effects of Aqueous Leaf Extract of Ipomoea Batatas(Sweet Potato) on Ammonium Chloride-Induced Kidney Damage in Adult Wistar Rats

Ipomoea batatasaqueous leaves extract is found to have medicinal flavonoids. The aim of this study is to investigate the effect of Ipomoea batatasaqueous leaves extract on Ammonium chloride induced kidney damage on adult Wistar rats. Thirty (30) rats were used for this study. The animals were grouped into six (6) groups with five (5) rats each. Group A served as control group, rats in Group B was treated with 100 mg/kg body weight of Ammonium chloride, rats in Group C was treated with 400 mg/kg body weight of Ipomoea batatasaqueous leaves extract, rats in Group D was treated with 1200 mg/kg body weight of Ipomoea batatasaqueous leaves extract, rats in Group E was treated with 100 mg/kg body weight of Ammonium chloride and 400 mg/kg body weight of Ipomoea batatasaqueous leaves extract, rats in Group F was treated with 100 mg/kg body weight of Ammonium chloride and 1200 mg/kg body weight of Ipomoea batatasaqueous leaves extract. The rats in all groups were sacrificed after 30 days.Five (5) ml blood samples were collect via direct cardiac puncture and stored in lithium heparin bottles for kidney function test and antioxidant assay analysis. The results showed significant increase (P<0.05) in urea and creatininelevels in groups B when compared to control and other groups, Oxidative stress analysis showed statistically significant increase (P>0.05) in MDA levels of groups B and F unlike group C, D and E when compared to control.There was no significant difference statistically in groups C, D, E and F SOD and CAT levels when compared with the control group. The levels of SODand CAT significantly decreased (P ? 0.05) in group B rats when compared to control group (A). Histological studies showed normal architectural structure of kidney tissues in all groups except the group treated with 100 mg/kg body weight of Ammonium chloride. It can be concluded thatIpomoea batataswas seen to havenephroprotective and antioxdative potentials.

Key Words: Ipomoea batatas, oxidative stress, nephrotoxicity