Coenzyme-Q10 and Omega-3 Fatty-Acid Ameliorates Catalepsy and Neuroinflammation in Haloperidol Induced Parkinson’s disease Mouse Model

The benefits of dietary supplements like co-enzyme Q10 (CQ10) and omega-3 fatty acids in reducing the burden of neurodegenerative diseases including Parkinson’s disease (PD) has recently become the focus of research. Also, because mitochondrial dysfunction and oxidative damage have been linked to the development of Parkinsonism, the use of coenzyme-Q10 and omega-3 fatty acid has been suggested. This study examined the effects of CQ10 and omega-3 fatty acid in haloperidol induced mouse model of PD. Sixty Adult male mice weighing 30-35g each were assigned into six groups (A-F) of 10animals each. Group A control, fed standard diet, Group B, ip haloperidol (HAL) while groups C, oral Levodopa Cabidopa (LD) plus ip haloperidol, D and E, CQ1O diet (120 mg/kg of feed) and omega-3 fatty acid (500 mg/kg of feed) diet respectively, following ip haloperidol. Group F co-administered CQ10 and omega-3 fatty acid diet with ip haloperidol. All were administered daily for 28 days. Behaviour of mice in catalepsy bar test was assessed, following which animals were sacrificed by cervical dislocation. Cerebral sections were homogenized for tumour necrotic factor ? (TNF-?) and cerebellar cortex also processed for histological study. Result showed a significant decrease in catalepsy score with HAL.CQ10.?-3 (p= 0.001) and an increase with HAL and HAL.LD. TNF-? decreased significantly with HAL.?-3, HAL.CQ10.?-3 and increased with HAL and HAL.LD. Haematoxylin and Eosin of the cerebellar cortex showed moderately depleted and cromatolyzed purkinje cells with HAL and HAL.LD, which appeared ameliorated in CQ10.?-3F.HAL and HAL.CQ10 groups. The study concluded that CQ10 or omega3 fatty acid alone or as adjunct, exerts ameliorative effects on neuroinflammation in haloperidol induced Parkinsonism in mice.

Key Words: Parkinson’s disease; Neuroinflammation; CoQ10; Omega3 fatty- acid