Attenuating Roles of Curcuma longa on Ketamine-induced Neurotoxicity on Hypothalamic-Pituitary-Ovarian Axis of Wistar Rats

The hypothalamic-pituitary-ovarian (HPO) system is mostly affected by toxins, which can cause infertility in mammals. This research investigated the role of Curcuma longa on Ketamine toxicity in the HPO axis of rats. Twenty-five female Wistar rats were assigned into five groups of five rats after seven days of acclimatization. Group A received water and served as control. Groups B, C, D, and E received 10 mg/kg of Ketamine intraperitoneally at intervals of 2 days for five times each, and Groups C, D, and E received 250 mg/kg, 400 mg/kg, and 600 mg/kg of Curcuma longa orally for 14 days. Blood samples were used to study hormonal concentrations and oxidative stress markers. The result showed a significant decrease in weight in the ketamine untreated group. The (5.78±0.04), malondialdehyde superoxide dismutase (SOD) (15.60±0.40), and catalase (CAT) (28.82±0.28) enzyme concentrations were also lowered in the ketamine group but showed improvement in the treated groups. The serum concentration of estrogen (E2), follicle-stimulating hormone (FSH), ant-diuretic hormone (ADH), luteinizing hormone (LH), lactate dehydrogenase (LDH), and cortisol were all lowered by ketamine compared to control at p?0.05, which was improved by the extract. The alterations caused by ketamine toxicity were ameliorated by C. longa. Ketamine is a toxic drug with increased MDA and Lowered antioxidants such as SOD, but C. longa may be very productive in reducing these toxic effects.

Key Words: Axis; Curcuma longa; disorders; ketamine; hypothalamo-pituitary; ovarian